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Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

The vasoprotective effects are most evident in models of diabetic retinopathy, where a hallmark of the disease is the breakdown of the BRB and subsequent retinal vascular leakage [61]

That such a study has not been done despite fifty years of interest in the molecule and a large commercial market in vials is itself informative about how much of the injectable use is driven by evidence and how much by momentum

The regulatory landscape is littered with recalled drugs that passed safety checks in initial short-term, small-scale approval trials, but foundered years after when danger signals emerged only after millions unwittingly took the medications